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大鼠植入人工神经移植物后的功能恢复——一项系统综述

Functional recovery after implantation of artificial nerve grafts in the rat- a systematic review.

作者信息

Sinis Nektarios, Kraus Armin, Tselis Nikolaos, Haerle Max, Werdin Frank, Schaller Hans-Eberhard

机构信息

Clinic for Hand, Plastic, Reconstructive and Burn Surgery, BG Trauma Center, Eberhard-Karls University, Schnarrenbergstrasse 95, D-72076 Tuebingen, Germany.

Dept of Radiotherapy, Hospital of Offenbach, Starkenburgring 66, D-63069 Offenbach, Germany.

出版信息

J Brachial Plex Peripher Nerve Inj. 2009 Oct 25;4:19. doi: 10.1186/1749-7221-4-19.

DOI:10.1186/1749-7221-4-19
PMID:19852862
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2770034/
Abstract

PURPOSE

The aim of this study was to compare functional data of different nerve-gap bridging materials evaluated in rat experiments by means of a systematic review.

MATERIALS AND METHODS

A systematic review was conducted, searching MEDLINE, HTS and CENTRAL to identify all trials evaluating functional recovery of artificial nerve conduits in the rat model.

RESULTS

There was a trend towards a favourable outcome of conduits coated with Schwann-cells compared to the plain synthetics. Histomorphometry, electrophysiology and muscle-weight correlated poorly with functional outcome.

CONCLUSION

Schwann-cell coated conduits showed promising results concerning functional recovery. Further standardization in outcome reporting is encouraged.

摘要

目的

本研究旨在通过系统评价比较在大鼠实验中评估的不同神经间隙桥接材料的功能数据。

材料与方法

进行了一项系统评价，检索MEDLINE、HTS和CENTRAL以识别所有评估大鼠模型中人工神经导管功能恢复的试验。

结果

与普通合成材料相比，涂有雪旺细胞的导管有取得良好结果的趋势。组织形态计量学、电生理学和肌肉重量与功能结果的相关性较差。

结论

涂有雪旺细胞的导管在功能恢复方面显示出有前景的结果。鼓励在结果报告方面进一步标准化。

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2
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The role of evaluation methods in the assessment of peripheral nerve regeneration through synthetic conduits: a systematic review. Laboratory investigation.评估方法在通过合成导管评估周围神经再生中的作用：一项系统评价。实验室研究。
J Neurosurg. 2007 Dec;107(6):1168-89. doi: 10.3171/JNS-07/12/1168.
4
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Comparative neuro tissue engineering using different nerve guide implants.使用不同神经导向植入物的比较性神经组织工程
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