适用于所有基因组的模型：转录工厂的作用。

A model for all genomes: the role of transcription factories.

作者信息

Cook Peter R

机构信息

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.

出版信息

J Mol Biol. 2010 Jan 8;395(1):1-10. doi: 10.1016/j.jmb.2009.10.031. Epub 2009 Oct 21.

DOI:10.1016/j.jmb.2009.10.031

PMID:19852969

Abstract

A model for all genomes involving one major architectural motif is presented: DNA or chromatin loops are tethered to "factories" through the transcription machinery-a polymerase (active or inactive) or its transcription factors (activators or repressors). These loops appear and disappear as polymerases initiate and terminate (and as factors bind and dissociate), so the structure is ever-changing and self-organizing. This model is parsimonious, detailed (and so easily tested), and incorporates elements found in various other models.

摘要

本文提出了一个适用于所有基因组的模型，该模型涉及一个主要的结构基序：DNA或染色质环通过转录机制——一种聚合酶（活性或非活性）或其转录因子（激活剂或抑制剂）与“工厂”相连。随着聚合酶的起始和终止（以及因子的结合和解离），这些环会出现和消失，因此结构不断变化且自我组织。该模型简洁、详细（因此易于测试），并纳入了其他各种模型中的元素。