Academic Neurology Unit, University of Sheffield, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
Neurol Clin. 2009 Nov;27(4):909-924. doi: 10.1016/j.ncl.2009.06.004.
Psychogenic non-epileptic seizures (PNES) are one of the most common differential diagnoses of epilepsy. PNES are poorly understood and often sub-optimally treated. This article summarizes current knowledge about the etiology of PNES. Through describing the interactions of predisposing, precipitating, perpetuating, and triggering factors, an integrated biopsychosocial model of a complex disorder is developed. PNES emerge as a dissociative response to a range of different stressors in vulnerable individuals. Once established, maintaining factors turn a temporary disturbance into a chronically disabling disorder.
心因性非癫痫性发作（PNES）是癫痫最常见的鉴别诊断之一。PNES 理解不足，且往往治疗效果欠佳。本文总结了目前关于 PNES 病因的知识。通过描述易感、诱发、持续和触发因素的相互作用，提出了一个复杂障碍的综合生物心理社会模型。PNES 是在易感性个体对一系列不同应激源产生的分离反应。一旦形成，维持因素将暂时的紊乱转变为慢性致残障碍。
