University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA.
Acta Histochem. 2011 Feb;113(2):150-5. doi: 10.1016/j.acthis.2009.09.006. Epub 2009 Oct 23.
PRDM16 is a member of the PR domain-containing protein family and is associated with various disease states including myelodysplastic syndrome and adult T-cell leukemia, as well as developmental abnormalities such as cleft palate. It is also known to act as a regulator of cell differentiation. Expression analysis of PRDM16 is limited, especially within the developing embryo. The current study evaluated the temporal and spatial localization of PRDM16 during early mouse development (embryonic days 8.5-14.5). PRDM16 was first detected on E9.5 in a limited number of tissues and by E14.5, was expressed in a broad range of developing tissues including those of the brain, lung, kidney, and gastrointestinal tract. The expression pattern is consistent with a role for PRDM16 in the development of multiple tissues. Collectively, these studies are the first to characterize the expression of the PRDM16 gene during early murine development.
PRDM16 是 PR 结构域蛋白家族的成员，与多种疾病状态相关，包括骨髓增生异常综合征和成人 T 细胞白血病，以及腭裂等发育异常。它也被认为是细胞分化的调节剂。PRDM16 的表达分析受到限制，特别是在发育中的胚胎中。本研究评估了 PRDM16 在早期小鼠发育过程中的时空定位（胚胎第 8.5 天至 14.5 天）。PRDM16 于 E9.5 日在少数组织中首次检测到，到 E14.5 日，在广泛的发育组织中表达，包括脑、肺、肾和胃肠道。表达模式与 PRDM16 在多种组织发育中的作用一致。总之，这些研究首次描述了 PRDM16 基因在早期小鼠发育过程中的表达情况。
