Pitt M J
University of Arizona Health Science Center, Tucson.
Radiol Clin North Am. 1991 Jan;29(1):97-118.
The terms rickets and osteomalacia describe gross, histologic, and radiologic abnormalities common to more than 50 diseases that vary in cause and clinical presentation. Rachitic and osteomalacic syndromes seen in current clinical practice usually are resistant to vitamin D forms and are most often caused by phosphate loss or 1,25(OH)2D deficiency, or both. Radiographic identification of rachitic or osteomalacic syndromes and accurate diagnosis of a particular cause is essential, as many patients' conditions can be improved or cured with proper therapy.
佝偻病和骨软化症这两个术语描述了50多种病因和临床表现各异的疾病所共有的大体、组织学和放射学异常。当前临床实践中所见的佝偻病和骨软化症综合征通常对维生素D制剂耐药,最常见的病因是磷丢失或1,25(OH)₂D缺乏,或两者兼有。对佝偻病或骨软化症综合征进行影像学识别并准确诊断特定病因至关重要,因为许多患者的病情通过适当治疗可以得到改善或治愈。