Roberts W A, Badger V M
J Pediatr Orthop. 1984 Sep;4(5):593-8.
Neonatal osteomalacia has received scant attention in the orthopedic literature, despite a reported incidence of 13-32% in very-low-birth-weight infants. This retrospective study focused on the calcium, phosphorus, and vitamin D metabolism of 10 surviving infants up to 28 weeks old born over a 30-month period. Clinical and radiologic evidence of osteomalacia appeared to be related to the intake of calcium and phosphorus. The lower the amount of mineral intake, the more severe was the clinical appearance of rickets. The amount of vitamin D intake, although low, did not correlate with the degree of clinical or radiographic abnormalities noted in these infants. There was an orderly appearance of radiographic changes that were dependent on the amount of mineral depletion. Recognition and identification of the early radiographic findings may lead to the early diagnosis and treatment of osteomalacia in the very-low-birth-weight infant. Prevention of fractures resulting from calcium, phosphorus, or vitamin D deficiency is the goal of early therapy.
尽管据报道极低出生体重婴儿中新生儿骨软化症的发病率为13% - 32%，但骨科文献对其关注甚少。这项回顾性研究聚焦于在30个月期间出生的10名存活的28周龄以下婴儿的钙、磷和维生素D代谢情况。骨软化症的临床和放射学证据似乎与钙和磷的摄入量有关。矿物质摄入量越低，佝偻病的临床表现就越严重。这些婴儿的维生素D摄入量虽低，但与所观察到的临床或放射学异常程度并无关联。放射学改变依矿物质缺乏程度而有序出现。认识和识别早期放射学表现可能有助于对极低出生体重婴儿骨软化症进行早期诊断和治疗。早期治疗的目标是预防因钙、磷或维生素D缺乏导致的骨折。
