Department of Chemistry and Plant Sciences Institutes, Iowa State University, 2756 Gilman, Ames, IA 50011, USA.
Curr Opin Chem Biol. 2009 Dec;13(5-6):626-32. doi: 10.1016/j.cbpa.2009.09.021. Epub 2009 Oct 23.
Carbohydrate arrays can provide facile analyses of carbohydrate-binding proteins, antibodies in serum, and enzyme activities with minimal quantities of sugar samples. Recent developments in detection methods for carbohydrate arrays, especially surface plasmon resonance (SPR) and mass spectrometry, have enabled not only qualitative but in some cases quantitative data analysis in a variety of multivalent display formats. These advancements make diagnostic tools based on carbohydrate arrays more promising for infectious disease detection, cancer monitoring, and vaccine development.
碳水化合物阵列可以为糖样品的最小量提供简便的分析，例如对糖结合蛋白、血清中的抗体和酶活性进行分析。最近碳水化合物阵列的检测方法的发展，特别是表面等离子体共振（SPR）和质谱，不仅使各种多价显示格式的定性数据分析成为可能，而且在某些情况下还可以进行定量数据分析。这些进步使基于碳水化合物阵列的诊断工具在传染病检测、癌症监测和疫苗开发方面更有前景。
