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前列腺高剂量率近距离放疗的实际考量

Practical considerations for prostate HDR brachytherapy.

作者信息

Slessinger Eric D

机构信息

Department of Radiation Oncology, IU Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

出版信息

Brachytherapy. 2010 Jul-Sep;9(3):282-7. doi: 10.1016/j.brachy.2009.05.003. Epub 2009 Oct 22.

Abstract

PURPOSE

A process for prostate high-dose-rate (HDR) brachytherapy was developed and implemented successfully in the community hospital setting. The practical aspects of the program are reviewed and may serve as a foundation for clinics interested in offering this clinical service.

METHODS AND MATERIALS

A generic needle distribution geometry was established to accommodate target volumes of variable size. A system to identify and assign treatment channels to each implant needle was devised. The computerized tomography (CT)-based treatment planning was used with dose constraints defined for sensitive structures and target uniformity. Implant needle stability was promoted by supporting the patient on a CT compatible padded sliding board. A process that aligns dwell position to CT imaging without the use of radiographic markers was followed. Graphical optimization of dwell times was used to generate the treatment dose distributions.

RESULTS

Prostate HDR brachytherapy as a boost or as monotherapy has been offered in a program that has evolved over the past 8 years. Practical aspects of the program promote its feasibility and precision. Collaboration with commercial entities has also led to the development of products that support the technique.

CONCLUSIONS

Prostate HDR brachytherapy offers a relatively high degree of dose distribution control in comparison with other prostate radiotherapy modalities. The practical aspects described offer assurance to achieve that goal.

摘要

目的

开发了一种前列腺高剂量率(HDR)近距离放射治疗方法,并在社区医院环境中成功实施。对该项目的实际情况进行了回顾,可为有兴趣提供此项临床服务的诊所提供基础。

方法和材料

建立了一种通用的针分布几何结构,以适应不同大小的靶体积。设计了一种识别并为每个植入针分配治疗通道的系统。基于计算机断层扫描(CT)的治疗计划结合了为敏感结构定义的剂量限制和靶区均匀性。通过将患者支撑在与CT兼容的带衬垫滑板上来提高植入针的稳定性。采用了一种在不使用放射标记的情况下将驻留位置与CT成像对齐的方法。利用驻留时间的图形优化来生成治疗剂量分布。

结果

在过去8年发展起来的一个项目中提供了前列腺HDR近距离放射治疗作为增强治疗或单一疗法。该项目的实际情况提高了其可行性和精确性。与商业实体的合作也促成了支持该技术的产品的开发。

结论

与其他前列腺放射治疗方式相比,前列腺HDR近距离放射治疗提供了相对较高程度的剂量分布控制。所描述的实际情况为实现该目标提供了保障。

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