Marsh Derek
Max-Planck-Institut für biophysikalische Chemie, Abteilung Spektroskopie und photochemische Kinetik, 37070 Göttingen, Germany.
Biochim Biophys Acta. 2010 Jan;1798(1):40-51. doi: 10.1016/j.bbamem.2009.10.010. Epub 2009 Oct 22.
For optimum function, biological membranes need a fluid environment, which is afforded by the liquid-disordered phase of lipids with low chain-melting temperatures or the liquid-ordered phase that is formed by combining high chain-melting lipids with cholesterol. The dependence of chain-melting transition temperature on lipid chain structure is therefore of central importance. The currently available database, including sphingolipids and glycolipids, is summarised here by parameterising systematic dependences on molecular structure in terms of suitable thermodynamic models. Chain-length dependence, chain asymmetry of lipids forming partially interdigitated and mixed interdigitated gel phases, chain unsaturation, positional dependence of methyl branching, headgroup-attached and alpha-branched chains, and length of zwitterionic headgroups are all covered. This type of information is essential for biophysical approaches to functional lipidomics.
为实现最佳功能，生物膜需要一个流体环境，这可由具有低链熔化温度的脂质的液相无序相或通过将高链熔化脂质与胆固醇结合形成的液相有序相提供。因此，链熔化转变温度对脂质链结构的依赖性至关重要。目前可用的数据库，包括鞘脂和糖脂，在此通过根据合适的热力学模型对分子结构的系统依赖性进行参数化来总结。涵盖了链长依赖性、形成部分交错和混合交错凝胶相的脂质的链不对称性、链不饱和度、甲基分支的位置依赖性、头基连接链和α分支链以及两性离子头基的长度。这类信息对于功能脂质组学的生物物理方法至关重要。
