Department of Neurology, University of Cincinnati, Cincinnati, OH 45267, USA.
Neuropharmacology. 2010 May;58(6):835-44. doi: 10.1016/j.neuropharm.2009.10.005. Epub 2009 Oct 22.
Stem cell research offers enormous potential for treating many diseases of the nervous system. At present, therapeutic strategies in stem cell research segregate into two approaches: cell transplantation or endogenous cell stimulation. Realistically, future cell therapies will most likely involve a combination of these two approaches, a theme of our current research. Here, we propose that there exists a 'synergy' between exogenous (transplanted) and endogenous stem cell actions that can be utilized to achieve therapeutic ends. Elucidating mechanisms underlying this exogenous-endogenous stem cell synergism may lead to the development of optimal cell therapies for neural disorders.
干细胞研究为治疗许多神经系统疾病提供了巨大的潜力。目前，干细胞研究中的治疗策略分为两种方法：细胞移植或内源性细胞刺激。实际上，未来的细胞疗法很可能涉及这两种方法的结合，这也是我们当前研究的主题。在这里，我们提出外源性（移植）和内源性干细胞作用之间存在“协同作用”，可以利用这种协同作用来达到治疗目的。阐明这种外源性-内源性干细胞协同作用的机制可能会为神经疾病的最佳细胞疗法的发展提供依据。
