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在小鼠中删除多巴胺 D4 受体（D4R）不会影响食物或可卡因的操作性反应。

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine.

机构信息

Laboratory of Neuroimaging, NIAAA, NIH, Bethesda, MD, USA.

出版信息

Behav Brain Res. 2010 Mar 5;207(2):508-11. doi: 10.1016/j.bbr.2009.10.020. Epub 2009 Oct 22.

DOI:10.1016/j.bbr.2009.10.020
PMID:19853629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2815086/
Abstract

In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine.

摘要

在这项研究中，我们使用 D4R 小鼠研究了 D4R 在食物和可卡因自我给药中的遗传贡献。检查了小鼠对食物丸或静脉内可卡因的操作性反应。与野生型小鼠（D4R(+/+))相比，杂合子（D4R(+/-))和敲除（D4R(-/-))小鼠对食物或可卡因的反应没有差异。我们的研究结果表明，D4R 不直接参与调节食物或可卡因的操作性反应行为。

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本文引用的文献

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J Psychopharmacol. 2010 Jun;24(6):897-904. doi: 10.1177/0269881109102613. Epub 2009 Mar 12.
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