Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA.
Schizophr Res. 2010 Mar;117(1):13-20. doi: 10.1016/j.schres.2009.09.030. Epub 2009 Oct 24.
Recently, a great deal of interest has arisen in resting state fMRI as a measure of tonic brain function in clinical populations. Most studies have focused on the examination of temporal correlation between resting state fMRI low-frequency oscillations (LFOs). Studies on the amplitudes of these low-frequency oscillations are rarely reported. Here, we used amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF; the relative amplitude that resides in the low frequencies) to examine the amplitude of LFO in schizophrenia. Twenty-six healthy controls and 29 patients with schizophrenia or schizoaffective disorder participated. Our findings show that patients showed reduced low-frequency amplitude in proportion to the total frequency band investigated (i.e., fALFF) in the lingual gyrus, left cuneus, left insula/superior temporal gyrus, and right caudate and increased fALFF in the medial prefrontal cortex and the right parahippocampal gyrus. ALFF was reduced in patients in the lingual gyrus, cuneus, and precuneus and increased in the left parahippocampal gyrus. These results suggest LFO abnormalities in schizophrenia. The implication of these abnormalities for schizophrenic symptomatology is further discussed.
最近，静息态 fMRI 作为临床人群紧张性脑功能的一种测量方法引起了极大的兴趣。大多数研究都集中在检查静息态 fMRI 低频振荡（LFO）之间的时间相关性。很少有研究报道这些低频振荡的幅度。在这里，我们使用低频波动幅度（ALFF）和分数低频波动幅度（fALFF；低频范围内的相对幅度）来检查精神分裂症患者的 LFO 幅度。共有 26 名健康对照者和 29 名精神分裂症或分裂情感障碍患者参与了研究。我们的研究结果表明，与所研究的总频带（即 fALFF）相比，患者的低频幅度降低，在舌回、左侧楔前叶、左侧岛叶/颞上回、右侧尾状核和内侧前额叶皮质和右侧海马旁回中增加了 fALFF。在舌回、楔前叶和楔叶中，ALFF 在患者中降低，而在左侧海马旁回中增加。这些结果表明精神分裂症患者存在 LFO 异常。进一步讨论了这些异常对精神分裂症症状的影响。
