Wang Xiao-Na, Ye Ping, Cao Rui-Hua, Yang Xu, Xiao Wen-Kai, Zhang Yun, Bai Yong-Yi, Wu Hong-Mei
Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.
J Clin Hypertens (Greenwich). 2015 Aug;17(8):594-600. doi: 10.1111/jch.12555. Epub 2015 Apr 20.
The authors investigated whether plasma total homocysteine (tHcy) is a predictive factor for arterial stiffness (carotid-femoral pulse wave velocity [cf-PWV] and carotid-radial PWV) in 1447 patients from a 4.8-year prospective study in Beijing, People's Republic of China. Baseline tHcy showed a significant relationship with follow-up cf-PWV (β=0.817, P=.015) in a multivariable linear regression analysis. A stepwise logistic regression model showed that baseline levels of tHcy were significantly associated with follow-up cf-PWV in the adjusted models. Furthermore, the baseline tHcy levels showed a significant association with increases in cf-PWV. There was no association between the change in tHcy and increase in PWV. The present study clearly demonstrated an association between tHcy levels and arterial stiffness, indicating that tHcy is an independent predictive factor for arterial stiffness in a community-based population.
作者在中国北京进行了一项为期4.8年的前瞻性研究，调查了1447例患者血浆总同型半胱氨酸（tHcy）是否为动脉僵硬度（颈股脉搏波速度[cf-PWV]和颈桡脉搏波速度）的预测因素。在多变量线性回归分析中，基线tHcy与随访cf-PWV显示出显著关系（β=0.817，P=0.015）。逐步逻辑回归模型显示，在调整模型中，tHcy的基线水平与随访cf-PWV显著相关。此外，基线tHcy水平与cf-PWV的增加显著相关。tHcy的变化与PWV的增加之间没有关联。本研究清楚地证明了tHcy水平与动脉僵硬度之间的关联，表明tHcy是社区人群中动脉僵硬度的独立预测因素。
