Di Bella Giuseppe, Madarena Mauro
Di Bella Foundation, Bologna, Italy.
Neuro Endocrinol Lett. 2009;30(3):312-21.
The synergetic use of Somatostatin, Melatonin, Retinoids, Vitamins C, D3, and E, Calcium, sulphated Aminoglucosides, and minimum doses of cyclophosphamide in a 70-year old male patient with inoperable scarcely differentiated oesophageal carcinoma, has provided, from the beginning of treatment in 1995 to the present date, an excellent quality of life, as well as a cure with functional recovery. This paper discusses the rationale and molecular action mechanisms of the treatment which has a differentiating, apoptotic anti-proliferation effect, preserving and enhancing, unlike chemo- and/or radiotherapy, both the trophic and functional capacity of organs and tissues, and immunity and antiblastic homeostasis. This result confirms the efficacy of this biological multiple treatment (MDB); it is also in line with the positive results already published on the use of MDB in low-grade NHL (66) and in stage 3 or 4 lung carcinomas (53). The MDB, with no need for hospitalisation, no toxicity and without in the least reducing working activity, gradually and slowly reduced, and then eliminated the tumour formation. According to the author, reporting this case is useful in order to call for greater interest in the possibilities offered to oncology by the MDB biological and receptor treatment.
1995年起，对一名70岁、患有无法手术的低分化食管癌男性患者，联合使用生长抑素、褪黑素、维甲酸、维生素C、D3和E、钙、硫酸氨基葡萄糖以及最小剂量的环磷酰胺进行治疗，从治疗开始至今，患者生活质量极佳，且实现了功能恢复的治愈。本文讨论了该治疗方法的基本原理和分子作用机制，该治疗具有分化、凋亡和抗增殖作用，与化疗和/或放疗不同，它能保留并增强器官和组织的营养及功能能力，以及免疫和抗胚细胞内稳态。这一结果证实了这种生物综合治疗（MDB）的有效性；这也与已发表的关于MDB用于低级别非霍奇金淋巴瘤（66）和3或4期肺癌（53）的阳性结果一致。MDB无需住院，无毒性，且丝毫不会降低工作能力，它逐渐缓慢地减少，然后消除了肿瘤形成。据作者称，报告该病例有助于引起人们对MDB生物和受体治疗为肿瘤学带来的可能性的更大关注。
