Di Bella Giuseppe, Colori Biagio
Di Bella Foundation, Rizzoli Institute, Scientific Research and Care Institute, Bologna, Italy.
Neuro Endocrinol Lett. 2012;33(3):249-56.
In 23 cases of carcinoma of the head and neck, the combined use of Somatostatin and/or its analogue Octreotide, prolactin inhibitors, Melatonin, Retinoids, Vitamin E, Vitamin D3, Vitamin C, Calcium, chondroitin-sulphate, and minimal oral doses of cyclophosphamide (50-100 mg/day) led to a decided increase in survival with respect to the median values reported in the literature for the same tumours and stages, together with an evident improvement in the quality of life, partial or complete objective responses and, in some cases, complete and stable cure with functional recovery. The rationale and the mechanisms of molecular biology of the treatment are discussed, showing that the treatment has a differentiating, apoptotic, antiproliferative, antiangiogenic and antimetastatic effect, and, unlike chemo- and/or radiotherapy, preserves and enhances the trophism and functionality of organs, tissues and immunitary and antitumoral homeostasis. This result, achieved without toxicity, demonstrates the efficacy of this biological multitherapy (Prof. Luigi Di Bella's method or DBM) and is in agreement with the positive results already published on the use of the DBM in various neoplastic diseases. We believe it is of use to report these cases to invite greater interest in the possibilities opened up by this biological multitherapy.
在23例头颈部癌患者中，联合使用生长抑素和/或其类似物奥曲肽、催乳素抑制剂、褪黑素、类视黄醇、维生素E、维生素D3、维生素C、钙、硫酸软骨素以及小剂量口服环磷酰胺（50 - 100毫克/天），相对于文献报道的相同肿瘤和分期的中位生存值，患者的生存期有显著延长，生活质量明显改善，出现部分或完全客观缓解，在某些情况下实现了完全稳定治愈且功能恢复。文中讨论了该治疗方法的基本原理和分子生物学机制，表明该治疗具有分化、凋亡、抗增殖、抗血管生成和抗转移作用，并且与化疗和/或放疗不同，它能维持并增强器官、组织的营养供应以及免疫和抗肿瘤内环境稳定。这一无毒副作用的结果证明了这种生物多疗法（路易吉·迪贝拉教授方法或DBM）的有效性，与此前已发表的关于DBM用于各种肿瘤疾病的阳性结果一致。我们认为报告这些病例有助于引起人们对这种生物多疗法所带来可能性的更大关注。
