Di Bella Giuseppe, Colori Biagio
Fondazione Di Bella, Bologna, Italy.
Neuro Endocrinol Lett. 2009;30(4):437-49.
The combined use (MDB) of Somatostatin, Melatonin, Retinoids, Vitamins E, C, and D3, with Calcium, Chondroitin sulfate, and microdoses of Cyclophosphamide in a seven-month old baby affected by a voluminous retroperitoneal neuroblastoma measuring 4 x 8 cm produced a 50% objective response in six months, an almost total response in one year and a complete response at 14 months, with cure and absence of disease for over ten years.
This paper discusses the rationale and the molecular mechanisms of action of the treatment which has a differentiating, apoptotic and antiproliferative effect, preserving and enhancing both the trophism and functionality of organs and tissues, and the neuroimmunoendocrine and antiblastic homeostasis. This result is in agreement with the positive results already published on the use of the MDB in lymphoproliferative diseases, in stage III and IV lung cancer, in breast cancer and in cancers of the upper aerodigestive epithelia. Without the need for hospitalisation and with no toxicity, the MDB rapidly reduced and then eliminated the voluminous tumoral mass, allowing a normal quality of life and a perfectly normal psychophysical development.
We believe it is of use to report this case in order to invite greater interest in the oncological possibilities offered by the immunoneuroendocrine and biological-receptorial properties of the MDB treatment.
一名7个月大的婴儿患有体积为4×8厘米的巨大腹膜后神经母细胞瘤，联合使用生长抑素、褪黑素、类视黄醇、维生素E、C和D3，以及钙、硫酸软骨素和小剂量环磷酰胺进行治疗（MDB），6个月时产生了50%的客观缓解，1年时几乎完全缓解，14个月时完全缓解，实现治愈且疾病未复发超过10年。
本文讨论了该治疗方法的基本原理和分子作用机制，其具有分化、凋亡和抗增殖作用，能维持并增强器官和组织的营养作用及功能，以及神经免疫内分泌和抗胚细胞内环境稳定。这一结果与已发表的关于MDB用于治疗淋巴增生性疾病、III期和IV期肺癌、乳腺癌以及上呼吸道消化道上皮癌的阳性结果一致。无需住院且无毒性，MDB迅速缩小并随后消除了巨大的肿瘤块，使患者能够拥有正常的生活质量和完全正常的身心发育。
我们认为报告该病例有助于引起人们对MDB治疗的免疫神经内分泌和生物受体特性所提供的肿瘤治疗可能性产生更大兴趣。
