Section of Academic Radiology, University of Sheffield, Sheffield, UK.
J Magn Reson Imaging. 2009 Nov;30(5):981-8. doi: 10.1002/jmri.21949.
To determine whether regional changes in lung ventilation in a group of pediatric cystic fibrosis (CF) patients following a course of chest physiotherapy could be detected with (3)He MRI.
The reproducibility of lung ventilation volume measurements obtained with (3)He lung magnetic resonance imaging (MRI) was established in a group of five children with CF age 6-15 years. The same methodology was then used to evaluate whether standard chest physiotherapy (percussion and drainage) had any immediate effect on regional ventilated lung volumes in a further group of nine age-matched CF children (5-15 years).
Global lung ventilation volumes remained the same within the limits of sensitivity derived from the reproducibility study; however, regional lung ventilation was observed to change in most patients after therapy.
(3)He MRI can be successfully used in children with CF, and has the sensitivity to detect regional quantitative changes in lung ventilation following chest physiotherapy.
通过（3）He 磁共振成像（MRI）确定一组接受胸部物理治疗的小儿囊性纤维化（CF）患者的肺通气区域性变化是否可以被检测到。
在一组年龄为 6-15 岁的 5 名 CF 儿童中，建立了（3）He 肺磁共振成像（MRI）测量肺通气量的重复性。然后，使用相同的方法评估标准胸部物理治疗（叩击和引流）是否对另外 9 名年龄匹配的 CF 儿童（5-15 岁）的区域性通气肺量有任何即时影响。
全局肺通气量在重复性研究得出的灵敏度范围内保持不变；然而，治疗后大多数患者的区域性肺通气量观察到变化。
（3）He MRI 可成功用于 CF 患儿，具有检测胸部物理治疗后肺通气区域性定量变化的敏感性。
