The London Breast Institute, Princess Grace Hospital, London, U.K.
Heat Pipe and Thermal Management Research Group, College of Engineering, Design and Physical Sciences, Brunel University, London, U.K.
In Vivo. 2024 Jan-Feb;38(1):1-39. doi: 10.21873/invivo.13407.
This paper explores the crucial role of cryogenic mediums in driving breakthroughs within the biomedical sector. The objective was to investigate, critically discuss, and present the current knowledge and state-of-the-art practices, along with the challenges and perspectives of the most common applications. Through an extensive literature review, this work aims to supplement existing research, offering a comprehensive and up-to-date understanding of the subject. Biomedical research involving cryogenic mediums is advancing on multiple fronts, including the development of advanced medical technologies, clinical treatments for life-threatening conditions, high-quality biospecimen preservation, and antimicrobial interventions in industrial food processing. These advances open new horizons and present cutting-edge opportunities for research and the medical community. While the current body of evidence showcases the impressive impact of cryogenic mediums, such as nitrogen, helium, argon, and oxygen, on revolutionary developments, reaching definitive conclusions on their efficiency and safety remains challenging due to process complexity and research scarcity with a moderate certainty of evidence. Knowledge gaps further underline the need for additional studies to facilitate cryogenic research in developing innovative technological processes in biomedicine. These advancements have the potential to reshape the modern world and significantly enhance the quality of life for people worldwide.
本文探讨了低温介质在推动生物医学领域突破方面的关键作用。目的是调查、批判性地讨论和呈现最常见应用的当前知识和最新实践、挑战和前景。通过广泛的文献回顾，本工作旨在补充现有研究，提供对该主题的全面和最新理解。涉及低温介质的生物医学研究正在多个方面取得进展，包括先进医疗技术的开发、危及生命状况的临床治疗、高质量生物样本的保存以及工业食品加工中的抗菌干预。这些进展开辟了新的视野，为研究和医学界提供了前沿机会。尽管目前的证据表明氮、氦、氩和氧等低温介质对革命性发展产生了巨大影响，但由于过程复杂性和研究稀缺性，对其效率和安全性得出明确结论仍然具有挑战性，证据确定性中等。知识空白进一步强调需要开展更多研究，以促进生物医学中创新技术过程的低温研究。这些进展有可能重塑现代世界，显著提高全球人民的生活质量。
