Trabue Christopher H, Bloch Karen C, Myers James W, Moorman Jonathan P
Department of Internal Medicine, James H Quillen College of Medicine, East Tennessee State University Medical Service, Johnson, TN 37614, USA.
Herpes. 2008 Nov;15(2):33-5.
Human herpesvirus type 6 (HHV-6) has been well described as an agent of meningoencephalitis in post-haematopoietic stem cell transplantation patients, but is a rare cause of meningoencephalitis in immunocompetent adults. We report an immunocompetent adult with HHV-6-associated meningoencephalitis. The patient was an elderly diabetic man who presented with fever and confusion, with cerebrospinal fluid (CSF) pleocytosis. HHV-6 DNA was amplified from CSF by polymerase chain reaction. In our review of the medical literature we examine clinical presentations, laboratory findings, neuroimaging studies, treatments and clinical outcomes in immunocompetent patients with HHV-6 meningoencephalitis.
人疱疹病毒6型（HHV-6）已被充分描述为造血干细胞移植后患者发生脑膜脑炎的病原体，但在免疫功能正常的成年人中，它是脑膜脑炎的罕见病因。我们报告了一名患有HHV-6相关性脑膜脑炎的免疫功能正常的成年人。该患者是一名老年糖尿病男性，表现为发热和意识模糊，伴有脑脊液（CSF）细胞增多。通过聚合酶链反应从脑脊液中扩增出HHV-6 DNA。在我们对医学文献的回顾中，我们研究了免疫功能正常的HHV-6脑膜脑炎患者的临床表现、实验室检查结果、神经影像学研究、治疗方法及临床结局。
