Webb Gemma, Leong Mei Yen Michelle, Bishop Emma, Sehu Marjoree
Monash University, Victoria, Australia.
Department of Infectious Diseases, Frankston Hospital, Peninsula Health, Victoria, Australia.
Open Forum Infect Dis. 2024 Sep 4;11(9):ofae501. doi: 10.1093/ofid/ofae501. eCollection 2024 Sep.
Human herpesvirus 6 (HHV-6) is associated with its presentation in the pediatric population as roseola infantum. Rarely, it is the causative agent of encephalitis, with most cases reported among the immunocompromised population due to reactivation. This review article analyzes the published records of cases labeled HHV-6 encephalitis in immunocompetent adults, aiming to understand the diagnostic methods behind each case and explore the complexities of such a diagnosis. We note significant variability in the methods used to come to a diagnosis of HHV-6 encephalitis, as well as inconsistent approaches to treatment of this condition. Given the rarity of HHV-6 encephalitis in immunocompetent adults, there are no clearly structured diagnostic guidelines for this condition in this patient population. We highlight several diagnostic methods that provide more convincing evidence of true HHV-6 encephalitis and may provide a basis for further development of guidelines for the diagnosis and treatment of this condition.
人类疱疹病毒6型（HHV - 6）在儿科人群中表现为幼儿急疹。极少情况下，它是脑炎的病原体，大多数病例报告发生在免疫功能低下人群中，由病毒再激活引起。这篇综述文章分析了免疫功能正常的成年人中标记为HHV - 6脑炎病例的已发表记录，旨在了解每个病例背后的诊断方法，并探讨这种诊断的复杂性。我们注意到用于诊断HHV - 6脑炎的方法存在显著差异，以及针对这种病症的治疗方法也不一致。鉴于免疫功能正常的成年人中HHV - 6脑炎罕见，在该患者群体中没有针对这种病症的明确结构化诊断指南。我们强调了几种诊断方法，这些方法为真正的HHV - 6脑炎提供了更有说服力的证据，并可能为进一步制定这种病症的诊断和治疗指南提供基础。
