Mistrangelo Massimiliano, Cassoni Paola, Scozzari Gitana, Castellano Isabella, Gavello Giorgia, Corno Franco, Morino Mario
Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy.
Tumori. 2009 Jul-Aug;95(4):538-41. doi: 10.1177/030089160909500424.
Granular cell tumor was first described by Abrikossoff in 1926. Over the years several cases of this neoplasm have been reported, with a variety of localizations. We here report a case of perianal granular cell tumor and discuss its histogenesis and its relevance to clinical practice.
The clinical course and histopathology of the case are reviewed, and a literature search for other reported cases has been performed.
A 46-year-old woman presented with a perianal nodular lesion. Pathological examination revealed a granular cell tumor. A literature search produced only 25 other cases of anal and perianal granular cell tumors.
Granular cell tumors are rarely observed in the perianal region. Their existence must always be borne in mind in the differential diagnosis of perianal neoplasms. In most cases surgical excision is curative, but potential malignant transformation must be considered during therapeutic procedures and follow-up.
颗粒细胞瘤于1926年由阿布里科索夫首次描述。多年来，已报道了该肿瘤的多例病例，其发生部位多种多样。我们在此报告一例肛周颗粒细胞瘤病例，并讨论其组织发生及其与临床实践的相关性。
回顾该病例的临床病程和组织病理学，并对其他已报道病例进行文献检索。
一名46岁女性出现肛周结节性病变。病理检查显示为颗粒细胞瘤。文献检索仅发现另外25例肛门和肛周颗粒细胞瘤病例。
颗粒细胞瘤在肛周区域很少见。在肛周肿瘤的鉴别诊断中必须始终牢记其存在。在大多数情况下，手术切除可治愈，但在治疗过程和随访中必须考虑潜在的恶性转化。
