Kelly Emily F, Stein Alan A, Ma Xiaoling Charlene, Yeguez Jose
Department of Surgery, Boca Raton Regional Hospital, Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA.
J Surg Case Rep. 2017 Jun 6;2017(6):rjw186. doi: 10.1093/jscr/rjw186. eCollection 2017 Jun.
Granular cell tumor (GCT) is a rare submucosal neoplasm most commonly localized in the oral mucosa; with one-third of all cases found in the tongue, with less than 30 cases of perianal GCT reported in the literature, making it a rare anal neoplasm. Wide local excision is the gold standard of treatment and follow-up includes annual colonoscopy due to the high incidence of reoccurrence. Here we describe a rare case of benign perianal GCT in a 29-year-old female who presented asymptomatically; however, pathology report revealed a S100 positive immunostaining pattern. GCT is an important differential to be included when evaluating a patient with an asymptomatic perianal submucosal lesion. Since GCT and Squamous Cell Carcinoma present with similar pseudoepitheliomatous hyperplasia of the epithelium it is important that a biopsy and immunohistochemical analysis be performed to allow for accurate diagnosis and appropriate treatment.
颗粒细胞瘤（GCT）是一种罕见的黏膜下肿瘤，最常见于口腔黏膜；所有病例中有三分之一发生在舌部，文献报道的肛周GCT病例少于30例，使其成为一种罕见的肛门肿瘤。广泛局部切除是治疗的金标准，由于复发率高，随访包括每年进行结肠镜检查。在此，我们描述了一例29岁无症状女性的罕见良性肛周GCT病例；然而，病理报告显示免疫染色模式为S100阳性。在评估无症状肛周黏膜下病变的患者时，GCT是一个需要鉴别的重要疾病。由于GCT和鳞状细胞癌表现出类似的上皮假上皮瘤样增生，因此进行活检和免疫组化分析以实现准确诊断和适当治疗非常重要。
