Wang Ting, Wang Kan, Yao Qing, Chen Jiang-hao, Ling Rui, Zhang Ju-liang, Dong Xiu-zhen, Fu Feng, Dou Ke-feng, Wang Ling
Third Department of General Surgery, Xijing Hospital, Xi'an, China.
Cancer Invest. 2010 Mar;28(3):295-303. doi: 10.3109/07357900802203658.
Based on cost-effective ratio, there has not yet been imaging methods suitable for breast cancer screening in young women. The aim of this study was to evaluate the sensitivity and specificity of the combination of electrical impedance scanning (EIS) and ultrasound in identifying breast cancer for young women, to calculate relative risks, and to determine whether there has been some more accurate imaging method used in early detection of breast cancer in young women. A prospective and multicenter clinical study was conducted in young women aged 45 years and under. The young women (583 cases) scheduled for mammary biopsy underwent EIS and ultrasound, respectively. EIS and ultrasound results were compared with final histopathology results. Study end points included sensitivities and specificities of EIS, ultrasound and the combination method, as well as relative probability of breast cancer of positive patients detected by the combination of EIS and ultrasound. Of the 583 cases, 143 were diagnosed with breast cancer. The sensitivities of EIS, ultrasound and the combination method were 86.7% (124/143), 72% (103/143), and 93.7% (134/143); the specificities were 72.9% (321/440), 82.5% (363/440), and 64.1% (282/440), and the relative possibilities of breast cancer for the positive young women detected by EIS, ultrasound, and the combination method were 8.67, 5.77, and 14.84, respectively. The combination of EIS and ultrasound is likely to become an applicable method for early detection of breast cancer in young women.
基于性价比，目前尚无适用于年轻女性乳腺癌筛查的成像方法。本研究旨在评估电阻抗扫描（EIS）和超声联合检查对年轻女性乳腺癌的诊断敏感性和特异性，计算相对风险，并确定是否存在更准确的早期检测年轻女性乳腺癌的成像方法。对45岁及以下的年轻女性进行了一项前瞻性多中心临床研究。计划进行乳腺活检的年轻女性（583例）分别接受了EIS和超声检查。将EIS和超声检查结果与最终组织病理学结果进行比较。研究终点包括EIS、超声及联合检查方法的敏感性和特异性，以及EIS和超声联合检查检测出的阳性患者患乳腺癌的相对概率。583例患者中，143例被诊断为乳腺癌。EIS、超声及联合检查方法的敏感性分别为86.7%（124/143）、72%（103/143）和93.7%（134/143）；特异性分别为72.9%（321/440）、82.5%（363/440）和64.1%（282/440），EIS、超声及联合检查方法检测出的阳性年轻女性患乳腺癌的相对概率分别为8.67、5.77和14.84。EIS和超声联合检查可能成为早期检测年轻女性乳腺癌的一种适用方法。
