Stojadinovic Alexander, Nissan Aviram, Gallimidi Zahava, Lenington Sarah, Logan Wende, Zuley Margarita, Yeshaya Arieh, Shimonov Mordechai, Melloul Moshe, Fields Scott, Allweis Tanir, Ginor Ron, Gur David, Shriver Craig D
Department of Surgery, Walter Reed Army Medical Center, 6900 Georgia Ave NW, Washington, DC 20307, USA.
J Clin Oncol. 2005 Apr 20;23(12):2703-15. doi: 10.1200/JCO.2005.06.155.
To evaluate the feasibility and patient satisfaction with electrical impedance scanning (EIS) for early detection of breast cancer in young women.
Women undergoing screening clinical breast examination, imaging, or biopsy were eligible for EIS examination with T-Scan 2000ED (Mirabel Medical Systems, Austin, TX). Multiple logistic regression analysis evaluated the association between clinical variables and EIS performance. Patients completed a screening EIS satisfaction questionnaire (1 = least satisfied to 5 = most satisfied).
Twenty-nine cancers were identified among 1,103 women. Sixty-six percent (19 of 29) of cancers were nonpalpable and 55% (16 of 29) were in women age < or = 50 years. EIS sensitivity and specificity in women younger than 40 years was 50% and 90%, respectively. Exogenous estrogen use (P < .001) and menopausal status (P = .007) correlated significantly with EIS performance. False-positive rates were increased in postmenopausal women and those taking exogenous hormones. No correlation was evident between EIS performance and family history, prior breast cancer, breast density, or palpability. EIS-positive women younger than age 40 were 4.5 times more likely to have breast carcinoma than were women randomly selected from the general population. Patients were highly satisfied with the comfort, speed, and reporting of EIS screening (mean score, 4.8).
EIS seems promising for early detection of breast cancer, and identification of young women at increased risk for having the disease at time of screening. Positive EIS-associated breast cancer risk compares favorably with relative risks of conditions commonly used to justify early breast cancer screening. Patients are satisfied with a screening paradigm involving breast EIS.
评估电阻抗扫描（EIS）用于早期检测年轻女性乳腺癌的可行性及患者满意度。
接受乳腺临床筛查、影像学检查或活检的女性有资格使用T-Scan 2000ED（Mirabel Medical Systems，奥斯汀，德克萨斯州）进行EIS检查。多因素逻辑回归分析评估临床变量与EIS性能之间的关联。患者完成一份EIS筛查满意度问卷（1 = 最不满意至5 = 最满意）。
在1103名女性中发现了29例癌症。66%（29例中的19例）的癌症触诊不到，55%（29例中的16例）发生在年龄≤50岁的女性中。40岁以下女性的EIS敏感性和特异性分别为50%和90%。外源性雌激素使用（P <.001）和绝经状态（P =.007）与EIS性能显著相关。绝经后女性和服用外源性激素的女性假阳性率增加。EIS性能与家族史、既往乳腺癌、乳腺密度或可触知性之间无明显相关性。40岁以下EIS阳性的女性患乳腺癌的可能性是从普通人群中随机选择的女性的4.5倍。患者对EIS筛查的舒适度、速度和报告非常满意（平均评分，4.8）。
EIS在早期检测乳腺癌以及识别筛查时患该病风险增加的年轻女性方面似乎很有前景。与常用于证明早期乳腺癌筛查合理性的疾病的相对风险相比，EIS相关的乳腺癌阳性风险具有优势。患者对涉及乳腺EIS的筛查模式感到满意。
