Department of Neurology, Research Group for Neurological Therapeutics, Biomedical Research Centre, Philipps-University Marburg, Hans-Meerwein-Strasse, 35043 Marburg, Germany.
Neurosci Biobehav Rev. 2010 Mar;34(4):487-99. doi: 10.1016/j.neubiorev.2009.10.006. Epub 2009 Oct 24.
Various immunotherapy strategies for APP transgenic mice have emerged in recent years. Specifically, active immunization with beta-amyloid (A beta) or passive immunization with anti-A beta-antibodies in APP transgenic mice has appeared most promising. Recent studies have shown that treatment of APP transgenic mice either with A beta(40/42) or A beta-specific antibodies can have beneficial effects in cognitive tasks. Active as well as passive immunization have been shown to affect spatial, non-spatial, emotional and object-related learning and memory. Such effects can be observed when treatments are applied prophylactically (before apparent A beta pathology) or therapeutically (after the development of A beta pathology) in APP transgenic mice. This review focuses on such cognitive outcomes of different active and passive immunization strategies in APP transgenic mice.
近年来，出现了多种针对 APP 转基因小鼠的免疫疗法策略。具体来说，在 APP 转基因小鼠中进行β-淀粉样蛋白（Aβ）的主动免疫或使用抗 Aβ 抗体的被动免疫似乎最有前景。最近的研究表明，用 Aβ（40/42）或 Aβ特异性抗体治疗 APP 转基因小鼠在认知任务中具有有益的效果。主动免疫和被动免疫都已被证明可以影响空间、非空间、情感和物体相关的学习和记忆。在 APP 转基因小鼠中，预防性（在明显的 Aβ病理学之前）或治疗性（在 Aβ病理学发展之后）应用这些治疗方法时，就可以观察到这些效果。这篇综述重点介绍了 APP 转基因小鼠中不同主动和被动免疫策略的这些认知结果。
