阿尔茨海默病疫苗接种：未来策略的最新进展。
Vaccination against Alzheimer disease: an update on future strategies.
作者信息
Fettelschoss Antonia, Zabel Franziska, Bachmann Martin F
机构信息
Saiba GmbH; Rämismühle, Switzerland; Dermataology; University Hospital of Zürich; Zürich, Switzerland.
Dermataology; University Hospital of Zürich; Zürich, Switzerland; The Jenner Institute; University of Oxford; Oxfordshire, UK.
出版信息
Hum Vaccin Immunother. 2014;10(4):847-51. doi: 10.4161/hv.28183. Epub 2014 Feb 17.
Abstract
Alzheimer disease is a devastating chronic disease without adequate therapy. More than 10 years ago, it was demonstrated in transgenic mouse models that vaccination may be a novel, disease-modifying therapy for Alzheimer. Subsequent clinical development has been a roller-coaster with some positive and many negative news. Here, we would like to summarize evidence that next generation vaccines optimized for old people and focusing on patients with mild disease stand a good chance to proof efficacious for the treatment of Alzheimer.
摘要
阿尔茨海默病是一种尚无充分治疗方法的毁灭性慢性疾病。十多年前，转基因小鼠模型研究表明，疫苗接种可能是一种针对阿尔茨海默病的新型疾病修饰疗法。随后的临床开发过程犹如过山车，有一些正面消息，但更多的是负面消息。在此，我们想总结证据表明，为老年人优化并专注于轻度疾病患者的新一代疫苗很有可能被证明对阿尔茨海默病的治疗有效。
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