乳腺发育和疾病中的基质。
Stroma in breast development and disease.
机构信息
Department of Anatomy & Cellular Biology, Sackler School, Tufts University School of Medicine, Boston, MA 02111, USA.
出版信息
Semin Cell Dev Biol. 2010 Feb;21(1):11-8. doi: 10.1016/j.semcdb.2009.10.003. Epub 2009 Oct 24.
Abstract
It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression. During development, mammary cell fate specification and differentiation require highly regulated contextual signals derived from the stroma. Likewise, during breast carcinoma development, the tissue stroma can provide tumor suppressing and tumor-promoting environments that serve to regulate neoplastic growth of the epithelium. This review focuses on the role of the stroma as a mediator of normal mammary development, as well as a critical regulator of malignant conversion and progression in breast cancer. Recognition of the important role of the stroma during the progression of breast cancers leads to the possibility of new targets for treatment of the initial breast cancer lesion as well as prevention of recurrence.
摘要
越来越明显的是，正常和恶性的乳腺组织的发展和进展都需要复杂的局部和全身基质相互作用。在发育过程中，乳腺细胞的命运决定和分化需要来自基质的高度调控的上下文信号。同样，在乳腺癌的发展过程中，组织基质可以提供肿瘤抑制和促进肿瘤的环境，以调节上皮的肿瘤生长。本综述重点介绍了基质作为正常乳腺发育的介质，以及乳腺癌恶性转化和进展的关键调节因子的作用。认识到基质在乳腺癌进展过程中的重要作用，为治疗原发性乳腺癌病变以及预防复发提供了新的治疗靶点的可能性。
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