Wozniak-Grygiel E, Zeglen S, Stanjek-Cichoracka A, Zakliczyński M, Kucewicz Czech E, Zembala M
Laboratory of Immunology and Transplantology, Silesian Centre for Heart Diseases, Zabrze, Poland.
Transplant Proc. 2009 Oct;41(8):3232-4. doi: 10.1016/j.transproceed.2009.07.103.
According to the World Health Organization, iodine excreted in urine is a measure of its supply. According to the International Council for Control of Iodine Deficiency Disorders (ICCIDD), the urinary iodine (UI) should be >100 microg I per 1 liter of urine. Severe deficiency (SID) is diagnosed when UI is <50 microg/L and a moderate deficiency (MID) when UI is <100 microg/L.
UI analysis among 32 heart transplant recipients (26 men and 6 women); of overall mean age of 50.4 +/- 12.6 years was performed using the modified Program Against Micronutrient Malnutrition method, a spectrophotometric measurement based on the Sandell-Kolthoff reaction. Results were compared with those of thyroid stimulating hormone (TSH; microIU/mL), of free tri-iodothyronine (FT3; pg/mL), and thyroxine (FT4; ng/dL).
The average UI among the whole group was 126.4 +/- 109.6 microg/L. SID occurred in 12 patients (37.5%) and MID in 4 (12.5%); namely, mean UI of 17.0 +/- 9.6 and 79.5 +/- 5.6, respectively. In the other 16 patients (50%), the average UI was high, namely, 220.1 +/- 72.1 IU/mL. TSH, FT3, and FT4 in the whole group were within normal ranges. However, FT4 values significantly differed when SID and MID patients were compared with those displaying the recommended UI: 0.8 +/- 0.2 and 0.9 +/- 0.1 versus 1.1 +/- 0.2 respectively (P < .05). We noted decreased values of TSH in 5 patients (15.6%) and of FT3 or FT4 in 6 subjects (18.8%).
There exists significant iodine deficiency among heart transplant recipients. Measurements of urinary iodine together with thyroid gland hormones may be essential to prevent thyroid gland disturbances in these patients.
根据世界卫生组织的说法，尿碘排泄量是碘供应情况的一种衡量指标。根据国际碘缺乏病控制理事会（ICCIDD）的标准，尿碘（UI）应大于每升尿液100微克碘。当尿碘低于50微克/升时诊断为严重碘缺乏（SID），低于100微克/升时诊断为中度碘缺乏（MID）。
对32名心脏移植受者（26名男性和6名女性）进行尿碘分析；总体平均年龄为50.4±12.6岁，采用改良的防治微量营养素营养不良方案方法，即基于桑德尔 - 科尔托夫反应的分光光度法测量。将结果与促甲状腺激素（TSH；微国际单位/毫升）、游离三碘甲状腺原氨酸（FT3；皮克/毫升）和甲状腺素（FT4；纳克/分升）的结果进行比较。
全组的平均尿碘为126.4±109.6微克/升。12名患者（37.5%）出现严重碘缺乏，4名患者（12.5%）出现中度碘缺乏；即平均尿碘分别为17.0±9.6和79.5±5.6。在其他16名患者（50%）中，平均尿碘较高，即220.1±72.1国际单位/毫升。全组的TSH、FT3和FT4均在正常范围内。然而，将严重碘缺乏和中度碘缺乏患者与尿碘水平达推荐值的患者相比时，FT4值有显著差异：分别为0.8±0.2和0.9±0.1，而尿碘达推荐值的患者为1.1±0.2（P<0.05）。我们注意到5名患者（15.6%）的TSH值降低，6名受试者（18.8%）的FT3或FT4值降低。
心脏移植受者中存在明显的碘缺乏。测量尿碘以及甲状腺激素对于预防这些患者的甲状腺功能紊乱可能至关重要。
