[高碘地区孕妇碘营养状况及新生儿甲状腺功能研究]

[Study on the iodine status of pregnant women and thyroid function of neonate in high iodine area].

作者信息

Zhang Gui-Qin, Sang Zhong-Na, Liu Hua, Zhang Shu-Fen, Wei Wei, Zhao Na, Tan Long, Zhang Wan-Qi

机构信息

Department of Nutrition and Food Hygiene, College of Public Health, Tianjin Medical University, Tianjin 300070, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Mar;46(3):225-7.

PMID:22800592

Abstract

OBJECTIVE

To reveal the iodine status of pregnant women and its impact on thyroid function of neonates in high iodine area.

METHODS

A total of 210 pregnant women were chosen from a hospital in Haixing county, Hebei province. Pregnant women's random urinary and neonates' cord blood were collected. The urinary iodine concentration (UIC) was examined by arsenic-cerium catalytic spectrophotometry. The levels of free triiodothyronine (FT3), free thyroxine (FT4) and sensitive thyroid-stimulating hormone (sTSH) in serum were measured by chemiluminescence.

RESULTS

The age of 210 pregnant women was (27.69 +/- 4.73) years old, whose urinary iodine median (inter-quartile range ) was 1240.70 (1292.68) microg/L. 84.3% (177/210) of the pregnant women had excessive iodine intake (UIC > or = 500 microg/L), 13.8% (29/210) had more than adequate iodine intake( UIC within 250 - 499 microg/L), 0.5% (1/210) had adequate iodine intake (UIC within 150 - 249 microg/L) and 1.4% (3/210) had insufficient iodine intake (UIC < 150 microg/L). The average serum level of FT3, FT4 in neonates were (2.93 +/- 0.59), (15.03 +/- 1.92) pmol/L, respectively. The median (inter-quartile range) of serum sTSH in neonates were 7.33 (5.59) mU/L 78.1% (164/210) of the neonates' serum TSH were beyond 5 mU/L. There were no correlation between pregnant women's urinary iodine level and neonates' serum FT3 and sTSH level (P > 0.05), but there was a positive correlation between pregnant women's urinary iodine level and neonates' serum FT4 level (P < 0.01). Serum FT4 level of the neonates with whose mothers had insufficient iodine intake ((12.99 +/- 1.10) pmol/L) were statistically lower than those with their mothers had excessive iodine intake (15.16 +/- 1.83) pmol/L) (P < 0.05).

CONCLUSION

Most of the pregnant women in high iodine area were excessive for iodine nutrition, but still a few pregnant women had insufficient iodine nutrition. The level of neonates' serum sTSH were relatively high and monitoring of risk of hypothyroidism and subclinical hypothyroidism should be strengthened.

摘要

目的

揭示高碘地区孕妇碘营养状况及其对新生儿甲状腺功能的影响。

方法

选取河北省海兴县某医院的210名孕妇。采集孕妇随机尿样和新生儿脐血。采用砷铈催化分光光度法检测尿碘浓度（UIC）。采用化学发光法测定血清中游离三碘甲状腺原氨酸（FT3）、游离甲状腺素（FT4）和敏感促甲状腺激素（sTSH）水平。

结果

210名孕妇年龄为（27.69±4.73）岁，尿碘中位数（四分位数间距）为1240.70（1292.68）μg/L。84.3%（177/210）的孕妇碘摄入过量（UIC≥500μg/L），13.8%（29/210）的孕妇碘摄入充足（UIC在250～499μg/L之间），0.5%（1/210）的孕妇碘摄入适宜（UIC在150～249μg/L之间），1.4%（3/210）的孕妇碘摄入不足（UIC＜150μg/L）。新生儿血清FT3、FT4平均水平分别为（2.93±0.59）、（15.03±1.92）pmol/L。新生儿血清sTSH中位数（四分位数间距）为7.33（5.59）mU/L，78.1%（164/210）的新生儿血清TSH超过5mU/L。孕妇尿碘水平与新生儿血清FT3、sTSH水平无相关性（P＞0.05），但与新生儿血清FT4水平呈正相关（P＜0.01）。母亲碘摄入不足的新生儿血清FT4水平（（12.99±1.10）pmol/L）低于母亲碘摄入过量的新生儿（15.16±1.83）pmol/L（P＜0.05）。