Izpisúa Belmonte Juan Carlos, Ellis James, Hochedlinger Konrad, Yamanaka Shinya
Center of Regenerative Medicine in Barcelona, Dr Aiguader 88, 08003 Barcelona, Spain.
Nat Rev Genet. 2009 Dec;10(12):878-83. doi: 10.1038/nrg2700. Epub 2009 Oct 27.
No-one can have failed to notice the splash that induced pluripotent stem (iPS) cells have made in the few years since somatic cells were first reprogrammed to pluripotency. But what is their real promise, where should research efforts be focused, and are we at a stage where we can replace embryonic stem cells? Four pioneering iPS cell researchers offer their personal insights into these and other questions of current debate. As well expressing hope for the improved understanding and treatment of human disease, they urge caution over safety and propose the establishment of iPS cell banks.
自体细胞首次被重编程为多能性细胞以来的短短几年间，诱导多能干细胞（iPS细胞）所引起的轰动效应，想必无人能够忽视。但它们真正的前景如何？研究工作应聚焦于何处？我们是否已达到可以替代胚胎干细胞的阶段？四位iPS细胞研究领域的先驱者就这些以及当前辩论中的其他问题分享了他们的个人见解。他们在表达对增进人类疾病理解和治疗的希望的同时，也敦促人们对安全性保持谨慎，并提议建立iPS细胞库。
