生物材料在推进诱导多能干细胞研究与治疗中的应用。
Application of biomaterials to advance induced pluripotent stem cell research and therapy.
作者信息
Tong Zhixiang, Solanki Aniruddh, Hamilos Allison, Levy Oren, Wen Kendall, Yin Xiaolei, Karp Jeffrey M
机构信息
Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital Harvard Medical School, Cambridge, MA, USA Harvard Stem Cell Institute, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.
Division of Biomedical Engineering, Department of Medicine, Center for Regenerative Therapeutics, Brigham and Women's Hospital Harvard Medical School, Cambridge, MA, USA Harvard Stem Cell Institute, Cambridge, MA, USA Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
出版信息
EMBO J. 2015 Apr 15;34(8):987-1008. doi: 10.15252/embj.201490756. Epub 2015 Mar 12.
Derived from any somatic cell type and possessing unlimited self-renewal and differentiation potential, induced pluripotent stem cells (iPSCs) are poised to revolutionize stem cell biology and regenerative medicine research, bringing unprecedented opportunities for treating debilitating human diseases. To overcome the limitations associated with safety, efficiency, and scalability of traditional iPSC derivation, expansion, and differentiation protocols, biomaterials have recently been considered. Beyond addressing these limitations, the integration of biomaterials with existing iPSC culture platforms could offer additional opportunities to better probe the biology and control the behavior of iPSCs or their progeny in vitro and in vivo. Herein, we discuss the impact of biomaterials on the iPSC field, from derivation to tissue regeneration and modeling. Although still exploratory, we envision the emerging combination of biomaterials and iPSCs will be critical in the successful application of iPSCs and their progeny for research and clinical translation.
诱导多能干细胞（iPSC）源自任何体细胞类型，具有无限的自我更新和分化潜能，有望彻底改变干细胞生物学和再生医学研究，为治疗使人衰弱的人类疾病带来前所未有的机遇。为克服传统iPSC诱导、扩增和分化方案在安全性、效率和可扩展性方面的局限性，生物材料最近受到了关注。除了解决这些局限性，生物材料与现有iPSC培养平台的整合还可以提供更多机会，以便在体外和体内更好地探究iPSC的生物学特性并控制其行为或其后代的行为。在此，我们讨论生物材料对iPSC领域从诱导到组织再生和建模的影响。尽管仍处于探索阶段，但我们设想生物材料和iPSC的新兴结合对于iPSC及其后代在研究和临床转化中的成功应用至关重要。
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