垂枝暗罗的成分。

Constituents of Polyalthia longifolia var. pendula.

作者信息

Lee Tzong-Huei, Wang Mei-Jhen, Chen Pi-Yu, Wu Tung-Ying, Wen Wu-Che, Tsai Fu-Yu, Lee Ching-Kuo

机构信息

College of Pharmacy, Taipei Medical University, Taipei, Taiwan 110, Republic of China.

出版信息

J Nat Prod. 2009 Nov;72(11):1960-3. doi: 10.1021/np900207z.

DOI:10.1021/np900207z

PMID:19860383

Abstract

Three new clerodane-type diterpenes, 6alpha,16-dihydroxycleroda-3,13-dien-15-oic acid (1), 6alpha,16-dihydroxycleroda-4(18),13-dien-15-oic acid (2), and 4alpha,18beta-epoxy-16-hydroxyclerod-13-en-15-oic acid (3), and four new protoberberine alkaloids, (-)-8-oxo-10-hydroxy-2,3,9-trimethoxyberberine (4), (-)-8-oxo-2,11-dihydroxy-3,10-dimethoxyberberine (5), (-)-8-oxo-11-hydroxy-2,3,9,10-tetramethoxyberberine (6), and (-)-8-oxo-2,10-dihydroxy-3,9,11-trimethoxyberberine (7), together with 11 known substances, were isolated from a methanol extract of the stems of Polyalthia longifolia var. pendula. The structures of 1-7 were elucidated on the basis of spectroscopic data analysis. Compounds were evaluated for their antiproliferative activities against A549 and MCF-7 cancer cells, and among the substances tested, only 16-oxo-cleroda-3,13-dien-15-oic acid (8) exhibited cytotoxicity.

摘要

从垂叶暗罗（Polyalthia longifolia var. pendula）茎的甲醇提取物中分离出三种新的克罗烷型二萜，即6α,16 - 二羟基克罗达 - 3,13 - 二烯 - 15 - 酸（1）、6α,16 - 二羟基克罗达 - 4(18),13 - 二烯 - 15 - 酸（2）和4α,18β - 环氧 - 16 - 羟基克罗达 - 13 - 烯 - 15 - 酸（3），以及四种新的原小檗碱生物碱，即(-)-8 - 氧代 - 10 - 羟基 - 2,3,9 - 三甲氧基小檗碱（4）、(-)-8 - 氧代 - 2,11 - 二羟基 - 3,10 - 二甲氧基小檗碱（5）、(-)-8 - 氧代 - 11 - 羟基 - 2,3,9,10 - 四甲氧基小檗碱（6）和(-)-8 - 氧代 - 2,10 - 二羟基 - 3,9,11 - 三甲氧基小檗碱（7），以及11种已知物质。通过光谱数据分析阐明了1 - 7的结构。对这些化合物针对A549和MCF - 7癌细胞的抗增殖活性进行了评估，在所测试的物质中，只有16 - 氧代 - 克罗达 - 3,13 - 二烯 - 15 - 酸（8）表现出细胞毒性。