Yu Chuan-lin, Zhu Zheng-guang, Lei Lin-sheng, Chang Hua-lei, Gao Hui-ling, Chen Na-na, Yang Xian-guo
Drug Research Institute, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2009 Oct;29(10):2133-4, 2137.
To observe the effects of lipopolysaccharides of Bacterium prodigiosum (BP-LPS) in inhibiting tumor growth and improving immunosuppression in mice.
In mice bearing S180 tumor and a mouse model of immunosuppression induced by cyclophosphamide (CTX), the tumor growth, indexes of the immune organs and peripheral white blood cell count were measured after intraperitoneal injection of BP-LPS.
Injections of BP-LPS (40 U/kg) for 8 consecutive days resulted in a significant inhibition of the tumor growth in mice bearing S180 tumor (P<0.01), with a dose-dependent increase of the spleen indexes but no obvious changes in the thymus indexes. Intraperitoneal injections of BP-LPS for 7 days inhibited the reduction of peripheral white blood cells and spleen indexes in immunosuppressive mice, but did not produce any significant changes in normal mice.
BP-LPS can inhibit the tumor growth in tumor-bearing mice and enhance the immune functions of immunosuppressive mice.
观察灵杆菌脂多糖（BP-LPS）对小鼠肿瘤生长的抑制作用及对免疫抑制状态的改善作用。
以接种S180肿瘤小鼠及环磷酰胺（CTX）诱导的免疫抑制小鼠为模型，腹腔注射BP-LPS后，检测肿瘤生长、免疫器官指数及外周血白细胞计数。
连续8天腹腔注射BP-LPS（40 U/kg）可显著抑制S180荷瘤小鼠肿瘤生长（P<0.01），脾脏指数呈剂量依赖性升高，胸腺指数无明显变化。腹腔注射BP-LPS 7天可抑制免疫抑制小鼠外周血白细胞及脾脏指数的降低，但对正常小鼠无明显影响。
BP-LPS可抑制荷瘤小鼠肿瘤生长，增强免疫抑制小鼠的免疫功能。
