Department of Molecular Cardiovascular Biology and Pharmacology, Ehime University Graduate School of Medicine, Shitsukawa, Tohon, Ehime 791-0295, Japan.
J Renin Angiotensin Aldosterone Syst. 2010 Mar;11(1):1-6. doi: 10.1177/1470320309347793. Epub 2009 Oct 27.
Recent clinical studies indicate that blockade of the renin-angiotensin system is important to prevent stroke, and accumulating results of basic research also indicate the possible involvement of the central renin-angiotensin system in ischaemic brain damage and cognition. When the angiotensin II type 1 receptor is blocked by an angiotensin type 1 receptor blocker, unbound angiotensin II acts preferentially on the angiotensin II type 2 (AT(2)) receptor. These results suggest the pathophysiological importance of the AT(2) receptor in the clinical use of angiotensin type 1 receptor blockers, which are widely used in patients with hypertension with the expectation of a decrease in the onset of cardiovascular and cerebrovascular disease. We review here the possible roles of AT(2) receptor activation in the brain, focusing on ischaemic stroke, cognitive function and neurogenesis, and potential effects of specific AT(2) receptor agonists.
最近的临床研究表明，阻断肾素-血管紧张素系统对于预防中风非常重要，而越来越多的基础研究结果也表明，中枢肾素-血管紧张素系统可能参与缺血性脑损伤和认知。当血管紧张素 II 型 1 型受体被血管紧张素 II 型 1 型受体阻滞剂阻断时，未结合的血管紧张素 II 优先作用于血管紧张素 II 型 2（AT(2)）受体。这些结果表明，在广泛用于高血压患者的血管紧张素 II 型 1 型受体阻滞剂的临床应用中，AT(2)受体具有重要的病理生理学意义，人们期望它能降低心血管和脑血管疾病的发病风险。我们在此回顾了 AT(2)受体激活在大脑中的可能作用，重点关注缺血性中风、认知功能和神经发生，以及特定的 AT(2)受体激动剂的潜在作用。
