酚酸 B 的所有立体异构体的全合成。
Total syntheses of all stereoisomers of phenatic acid B.
机构信息
Department of Chemistry, Indian Institute of Technology Bombay, Powai 400076 Mumbai, Maharashtra India.
出版信息
J Org Chem. 2009 Nov 20;74(22):8826-9. doi: 10.1021/jo901927w.
PMID:19863073
Abstract
The total syntheses of all stereoisomers of phenatic acid B and determination of their absolute configuration are described. The synthetic strategy is based on an efficient combination of the Sharpless asymmetric dihydroxylation, the Johnson-Claisen rearrangement, and hydroboration-oxidation. It involves 11-12 steps and overall yield of 5-8%.
摘要
本文描述了全合成 phenatic 酸 B 的所有立体异构体并确定了它们的绝对构型。该合成策略基于 Sharpless 不对称双羟化、Johnson-Claisen 重排和硼氢化-氧化的有效组合。它涉及 11-12 步，总收率为 5-8%。
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