Shi Daqing, Rong Shaofeng, Dou Guolan, Wang Manman
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, PR China.
J Comb Chem. 2010 Jan-Feb;12(1):25-30. doi: 10.1021/cc900073w.
A series of new naphtho[1,2-e][1,3]oxazine derivatives such as trans-1,3-diaryl-1H-naphtho[1,2-e][1,3]oxazine-2(3H)-carbonyl chloride, 1-aryl-2-benzyl-1,2- dihydronaphtho[1,2-e][1,3]oxazine-3-one, and trans-1,3-diaryl-1H-naphtho[1,2-e] [1,3]oxazine-2(3H)-carbaldehyde were selectively synthesized via a chemoselective reaction of 1,3-diaryl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazines and triphosgene or triethyl orthoformate, respectively, induced by different low-valent titanium systems. This method has the advantages of short reaction time (15 min), convenient manipulation, and high chemoselectivity.
通过不同低价钛体系分别诱导1,3 - 二芳基 - 2,3 - 二氢 - 1H - 萘并[1,2 - e][1,3]恶嗪与三光气或原甲酸三乙酯的化学选择性反应，选择性地合成了一系列新的萘并[1,2 - e][1,3]恶嗪衍生物，如反式 - 1,3 - 二芳基 - 1H - 萘并[1,2 - e][1,3]恶嗪 - 2(3H) - 碳酰氯、1 - 芳基 - 2 - 苄基 - 1,2 - 二氢萘并[1,2 - e][1,3]恶嗪 - 3 - 酮和反式 - 1,3 - 二芳基 - 1H - 萘并[1,2 - e][1,3]恶嗪 - 2(3H) - 甲醛。该方法具有反应时间短（15分钟）、操作方便和化学选择性高的优点。
