Dou Guolan, Shi Chunling, Shi Daqing
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, P. R. China.
J Comb Chem. 2008 Nov-Dec;10(6):810-3. doi: 10.1021/cc8000844. Epub 2008 Aug 26.
1,2,3,5-Tetrasubstituted and 1,2,3,4,5-pentasubstituted pyrroles may be synthesized through three-component reaction of 1,3-diketones, aldehydes, and amines induced by low-valent titanium reagent. High regioselectivity was achieved. Compared with the classical synthetic method, this new method has the advantages of short reaction time (15 min), high yields, convenient manipulation, and high regioselectivity.
1,2,3,5-四取代和1,2,3,4,5-五取代吡咯可通过低价钛试剂诱导的1,3-二酮、醛和胺的三组分反应合成。实现了高区域选择性。与经典合成方法相比，这种新方法具有反应时间短（15分钟）、产率高、操作方便和区域选择性高的优点。
