Ganiu Moshood O, Nepal Binod, Van Houten Joshua P, Kartika Rendy
Department of Chemistry, 232 Choppin Hall, Louisiana State University, Baton Rouge, LA 70803 United States.
Tetrahedron. 2020 Nov 20;76(47). doi: 10.1016/j.tet.2020.131553. Epub 2020 Sep 6.
This review article highlights selected advances in triphosgene-enabled organic synthetic reactions that were reported in the decade of 2010-2019. Triphosgene is a versatile reagent in organic synthesis. It serves as a convenient substitute for the toxic phosgene gas. Despite its first known preparation in the late 19th interestingly began only three decades ago. Despite the relatively short history, triphosgene has been proven to be very useful in facilitating the preparation of a vast scope of value-added compounds, such as organohalides, acid chlorides, isocyanates, carbonyl addition adducts, heterocycles, among others. Furthermore, applications of triphosgene in complex molecules synthesis, polymer synthesis, and other techniques, such as flow chemistry and solid phase synthesis, have also emerged in the literature.
这篇综述文章重点介绍了2010年至2019年这十年间报道的光气参与的有机合成反应的一些进展。双光气是有机合成中的一种通用试剂。它是有毒光气气体的便捷替代品。尽管它最早是在19世纪末制备的，但有趣的是，其在有机合成中的应用仅仅在三十年前才开始。尽管历史相对较短，但双光气已被证明在促进制备各种增值化合物方面非常有用，例如有机卤化物、酰氯、异氰酸酯、羰基加成加合物、杂环化合物等。此外，双光气在复杂分子合成、聚合物合成以及其他技术（如流动化学和固相合成）中的应用也已出现在文献中。
