Vaccine Research Institute of San Diego, San Diego, CA 92121, USA.
Expert Rev Vaccines. 2009 Nov;8(11):1565-73. doi: 10.1586/erv.09.121.
The first virus-like particle to be tested for use as a vaccine carrier was based on the hepatitis B virus nucleocapsid protein. This viral subunit, while not infectious on its own, is a 36-nm particle that is highly immunogenic during a natural infection. The self-assembly and high degree of immunogenicity is maintained when expressed as a recombinant protein and, moreover, can confer a high degree of immunogenicity on foreign antigens linked to the particle, either chemically or genetically. This review describes the current state of the hepadnaviral core protein as a vaccine carrier.
作为疫苗载体而进行测试的首个类病毒颗粒是基于乙型肝炎病毒核衣壳蛋白。这种病毒亚单位本身并无感染性，但在自然感染过程中是一种 36nm 的颗粒，具有高度的免疫原性。当作为重组蛋白表达时，其自组装和高度免疫原性得以保持，而且，通过化学或遗传方法与颗粒相连的外来抗原也能赋予高度的免疫原性。本综述描述了作为疫苗载体的肝病毒核心蛋白的现状。
