Lopez-Escamez Jose A, Moreno Antonia, Bernal Monica, Perez-Garrigues Herminio, Santos-Perez Sofia, Soto-Varela Andres, Aran Ismael, Fernandez-Sanfrancisco Omar, Lopez-Nevot Alicia, Lopez-Nevot Miguel A
Otology & Neurotology Group, Department of Otolaryngology, Hospital de Poniente de Almería, Ctra. de Almerimar s/n, El Ejido, Almería.
Acta Otolaryngol. 2009 Nov;129(11):1222-5. doi: 10.3109/00016480802684080.
The longer alleles (CA)17-20 of the promoter region of PARP-1 gene may confer some protection against bilateral Meniere's disease (BMD).
To analyze microsatellite (CA)(n) polymorphisms in the promoter region of PARP-1 gene and seek out risk and protective variants for BMD.
Eighty patients from two ethnically defined groups with definite BMD, according to the diagnostic scale of the American Academy of Otolaryngology Head and Neck Surgery, were compared with a group of 371 normal controls from the same origin in a prospective multicenter study. We developed a specific amplification protocol to determine the PARP1-promotor CA microsatellite polymorphisms.
We found that the longer alleles (CA)17-20 had a very low frequency in BMD (2/160, 1.3%, OR=7.33 (1.77-30.37, 95% CI), corrected p=0.012), suggesting that it may confer some protection against BMD.
聚（ADP - 核糖）聚合酶 - 1（PARP - 1）基因启动子区域较长的等位基因（CA）17 - 20可能对双侧梅尼埃病（BMD）具有一定的保护作用。
分析PARP - 1基因启动子区域的微卫星（CA）（n）多态性，寻找BMD的风险和保护变异体。
在前瞻性多中心研究中，根据美国耳鼻咽喉头颈外科学会的诊断标准，将80例来自两个种族明确的确诊BMD患者组与371例来自同一来源的正常对照组进行比较。我们开发了一种特定的扩增方案来确定PARP1启动子CA微卫星多态性。
我们发现较长的等位基因（CA）17 - 20在BMD中的频率非常低（2/160，1.3%，OR = 7.33（1.77 - 30.37，95%CI），校正p = 0.012），表明它可能对BMD具有一定的保护作用。
