Facultad de Química, Departamento de Biología, Universidad Nacional Autónoma de México, Edificio F, Mexico City, Mexico.
Free Radic Res. 2009;43(11):1122-32. doi: 10.1080/10715760903214447.
Cisplatin (CDDP) is a chemotherapeutic agent that produces nephrotoxicity associated with oxidative/nitrosative stress. alpha-Mangostin (alpha-M) is a xanthone extracted from mangosteen with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the renoprotective effect of alpha-M on the CDDP-induced nephrotoxicity. alpha-M was administered (12.5 mg/kg/day, i.g.) for 10 days (7 days before and 3 days after CDDP injection). On day 7, rats were treated with a single injection of CDDP (7.5 mg/Kg, i.p.); 3 days after the rats were killed. alpha-M attenuated renal dysfunction, structural damage, oxidative/nitrosative stress, decrease in catalase expression and increase in mRNA levels of tumour necrosis factor alpha and transforming growth factor beta. In conclusion the renoprotective effect of alpha-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity.
顺铂（CDDP）是一种产生与氧化/硝化应激相关的肾毒性的化疗药物。α-倒捻子素（α-M）是从山竹果中提取的一种黄烷酮，具有抗氧化和抗炎特性。本研究旨在评估α-M 对 CDDP 诱导的肾毒性的保护作用。α-M （12.5mg/kg/天，口服）给药 10 天（CDDP 注射前 7 天和后 3 天）。第 7 天，大鼠单次注射 CDDP（7.5mg/Kg，腹腔注射）；3 天后大鼠被杀死。α-M 减轻了肾功能障碍、结构损伤、氧化/硝化应激、过氧化氢酶表达降低和肿瘤坏死因子-α和转化生长因子-βmRNA 水平升高。总之，α-M 对 CDDP 诱导的肾毒性的肾保护作用与氧化/硝化应激和炎症及纤维化标志物的减轻以及过氧化氢酶活性的维持有关。
