State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, PR China.
Chem Commun (Camb). 2009 Nov 21(43):6604-6. doi: 10.1039/b914315g. Epub 2009 Sep 15.
Highly regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane (FBSM) has been realized by Ir(COD)Cl/phosphoramidite, affording enantiopure fluorobis(phenylsulfonyl)methylated compounds bearing a terminal alkene, which could be converted to monofluoro-methylated ibuprofen in just two steps without loss of the optical purity (95% ee).
通过Ir(COD)Cl/手性膦酰胺配体，实现了氟代双(苯磺酰基)甲烷（FBSM）的高区域和对映选择性烯丙基烷基化反应，得到了末端烯烃取代的对映纯氟代双(苯磺酰基)甲基化化合物，这些化合物可以在不损失光学纯度（95%ee）的情况下，通过两步反应转化为单氟甲基化的布洛芬。
