Wilson P W, Anderson K M, Castelli W P
Framingham Heart Study, Massachusetts 01701.
Am J Med. 1991 Jan;90(1):11-6. doi: 10.1016/0002-9343(91)90500-w.
To provide information on the incidence of coronary heart disease (CHD) in the offspring of the original cohort from the Framingham Heart Study.
From 1972 to 1974, offspring of the original participants in the Framingham Heart Study underwent a baseline examination for standard cardiovascular risk factors. At entry into the study, these offspring were 30 to 59 years old and free of CHD. They were followed for 12 years, during which time 156 of 1,663 men and 55 of 1,714 women developed CHD.
In a multivariate proportional hazards model, CHD was significantly associated with age, lower high-density lipoprotein cholesterol (HDL-C) levels, and number of cigarettes smoked. Fasting glucose levels and low-density lipoprotein cholesterol (LDL-C) were highly associated with CHD in men, but borderline in women, while triglycerides and very-low-density lipoprotein cholesterol were not significantly associated with CHD after adjustment for HDL-C and glucose. Blood pressure medication was used in half of the hypertensive individuals, and systolic pressure was associated with CHD in women only.
This study confirms the importance of the common CHD risk factors of cigarette smoking and LDL-C, and extends the prognostic role of HDL-C in a middle-aged cohort. The impact of blood pressure, with or without use of hypertensive medications, was reduced in this study, and the data suggest that this attenuation was due to successful treatment.
提供有关弗雷明汉心脏研究初始队列后代中冠心病（CHD）发病率的信息。
1972年至1974年，弗雷明汉心脏研究初始参与者的后代接受了标准心血管危险因素的基线检查。进入研究时，这些后代年龄在30至59岁之间，且无冠心病。他们被随访了12年，在此期间，1663名男性中有156人、1714名女性中有55人患上了冠心病。
在多变量比例风险模型中，冠心病与年龄、较低的高密度脂蛋白胆固醇（HDL-C）水平以及吸烟数量显著相关。空腹血糖水平和低密度脂蛋白胆固醇（LDL-C）在男性中与冠心病高度相关，但在女性中处于临界状态，而甘油三酯和极低密度脂蛋白胆固醇在调整HDL-C和血糖后与冠心病无显著关联。一半的高血压患者使用了降压药物，收缩压仅在女性中与冠心病相关。
本研究证实了吸烟和LDL-C等常见冠心病危险因素的重要性，并扩展了HDL-C在中年队列中的预后作用。本研究中血压（无论是否使用降压药物）的影响有所降低，数据表明这种减弱是由于成功治疗所致。
