Hunterian Laboratory of Experimental Pathology, Johns Hopkins Medical School, Baltimore.
J Exp Med. 1911 Jan 5;13(1):115-35. doi: 10.1084/jem.13.1.115.
These experiments indicate that, in obstructive jaundice, the bile which escapes from the liver is absorbed by the hepatic capillaries and carried by the blood to the kidneys. The presence of a thoracic duct fistula influences in no way the development of icterus after total obstruction of the common bile duct. Bile pigments, sufficient to give a Salkowski test, may or may not appear in the lymph of the thoracic duct in such experiments, their appearance possibly depending upon the rapidity of bile secretion and the amount of lymph flow. Chronic icterus developing in an animal with a thoracic duct fistula gives an interesting distribution of bile pigments in the body fluids. The lymph and pericardial fluid contain the same amount, which is much less than the content of bile pigment in the blood serum and urine. It seems clear that in both acute and chronic obstructive jaundice the lymphatic apparatus takes no essential or active part in the absorption of bile pigments from the liver. At best, the lymphatic system is a secondary factor in the mechanism of jaundice.
这些实验表明，在阻塞性黄疸中，从肝脏逸出的胆汁被肝毛细血管吸收，并随血液被运送到肾脏。胸导管瘘的存在对胆总管完全阻塞后黄疸的发展没有任何影响。在这些实验中，胸导管淋巴中可能出现也可能不出现足以进行 Salkowski 试验的胆汁色素，其出现可能取决于胆汁分泌的速度和淋巴流量。在带有胸导管瘘的动物中发展的慢性黄疸在体液中显示出有趣的胆汁色素分布。淋巴和心包液中的含量相同，远低于血清和尿液中胆汁色素的含量。很明显，在急性和慢性阻塞性黄疸中，淋巴系统都没有从肝脏吸收胆汁色素的必要或主动作用。充其量，淋巴系统是黄疸机制中的次要因素。
