获得性血管性血友病综合征。治疗与诊断意义。
Acquired von Willebrand's syndrome. Therapeutic and diagnostic implications.
作者信息
Brownlee R E, Shockley W W
机构信息
Division of Otolaryngology-Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill 27599-7070.
出版信息
Arch Otolaryngol Head Neck Surg. 1991 Jan;117(1):106-8. doi: 10.1001/archotol.1991.01870130112028.
Acquired von Willebrand's syndrome is a newly recognized bleeding diathesis thought to be caused by autoantibodies to the von Willebrand factor. Acquired von Willebrand's syndrome has been reported in association with lymphoproliferative disorders and benign monoclonal gammopathies. Clinical features and laboratory abnormalities of this disease are similar to congenital von Willebrand's disease, but the optimal treatment may differ. We describe a 75-year-old man with chronic lymphocytic leukemia and recurrent epistaxis and also discuss the pathogenesis, diagnosis, and treatment of both the congenital and acquired disorders.
获得性血管性血友病综合征是一种新认识的出血性素质，被认为是由针对血管性血友病因子的自身抗体引起的。获得性血管性血友病综合征已被报道与淋巴增殖性疾病和良性单克隆丙种球蛋白病有关。这种疾病的临床特征和实验室异常与先天性血管性血友病相似，但最佳治疗方法可能不同。我们描述了一名75岁患有慢性淋巴细胞白血病且反复鼻出血的男性，并讨论了先天性和获得性疾病的发病机制、诊断和治疗。
Zotero 插件