Department of Experimental Bacteriology of the Mayo Foundation, Rochester, Minnesota.
J Exp Med. 1921 Jul 31;34(2):147-66. doi: 10.1084/jem.34.2.147.
Evidence is presented to show that there is no hemolytic toxin producing the anemia in pernicious anemia. Partial evidence is presented to show that the periods of active blood destruction which are seen as the exception in pernicious anemia cases during a series of transfusions are due to the activity of the blood-destroying organs of the body rather than to the intrinsic weakness of the pernicious anemia blood corpuscle. It is questionable whether blood destruction is as important a factor in producing the anemia of pernicious anemia as it is at present usually assumed to be.
有证据表明，巨幼细胞性贫血中并不存在产生贫血的溶血毒素。有部分证据表明，在一系列输血过程中，作为巨幼细胞性贫血病例中的例外而出现的活跃的血液破坏期，是由于身体的血液破坏器官的活动所致，而不是由于巨幼细胞性贫血血红细胞的内在弱点所致。目前通常认为，血液破坏在导致巨幼细胞性贫血的贫血中是一个重要因素，但这种说法是否正确值得怀疑。
