Varis K, Stenman U H, Lehtola J, Siurala M
Acta Hepatogastroenterol (Stuttg). 1978 Feb;25(1):62-7.
34 subjects including 5 probands with pernicious anemia, 3 probands with severe atriphic body gastritis and 26 of their first-degree relatives were studied gastroscopically, bioptically, functionally and immunologically. In general, members of the same family revealed a trend to behave similarly with respect to the parameters studied. Signs of A-gastritis (severe atrophy of gastric body glands with a normal or almost normal antrum, achlorhydria, hypergastrinemia and parietal cell antibodies), with intrinsic factor antibodies in the gastric juice and diminished intrinsic factor secretion without anemia were found both in families of probands with atrophic gastritis and pernicious anemia. This suggests a close etiopathogenetic relation of this type of mucosal lesion to overt pernicious anemia. Determination of HCl output and serum gastrin level enabled us to distinguish two differently behaving subgroups in the series, one of them with characteristics of overt adult pernicious anemia. Very low intrinsic factor secretion was found almost exclusively in connection with the presence of intrinsic factor antibodies in the gastric juice and always with severe atrophy of gastric body glands.
对34名受试者进行了胃镜检查、活检、功能检查和免疫检查，其中包括5名恶性贫血先证者、3名严重萎缩性胃体胃炎先证者及其26名一级亲属。总体而言，同一家族的成员在所研究的参数方面表现出相似的趋势。在萎缩性胃炎和恶性贫血先证者的家族中，均发现了A型胃炎的体征（胃体腺严重萎缩，胃窦正常或几乎正常，胃酸缺乏，高胃泌素血症和壁细胞抗体），胃液中存在内因子抗体，内因子分泌减少但无贫血。这表明这种类型的黏膜病变与明显的恶性贫血之间存在密切的病因学关系。测定胃酸分泌量和血清胃泌素水平使我们能够在该系列中区分出两个行为不同的亚组，其中一个具有明显成人恶性贫血的特征。极低的内因子分泌几乎仅与胃液中存在内因子抗体有关，并且总是与胃体腺的严重萎缩有关。
