大豹纹蛾所致皮炎的病理学研究。

PATHOLOGY OF THE DERMATITIS CAUSED BY MEGALOPYGE OPERCULARIS, A TEXAN CATERPILLAR.

机构信息

Department of Comparative Pathology, George Fabyan Foundation, Harvard Medical School, Boston.

出版信息

J Exp Med. 1922 Apr 30;35(5):737-53. doi: 10.1084/jem.35.5.737.

DOI:10.1084/jem.35.5.737

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2128124/

Abstract

The dermatitis caused by contact with the larva of Megalopyge opercularis is produced by a poison introduced by the hollow, specialized setae of its cuticular tubercles. It is not produced by the ornamental hairs, or by the tissue juices of the animal. 2. The poison appears to be of the nature of a venom, combined with protein vehicles, and may be itself a protein. 3. It is rendered inert by boiling, or by heating to 55 degrees C. for a considerable period of time. 4. It is apparently stored in sacs at the base of the setae, but whether secreted there, or by hypodermal glands, remains to be determined. 5. It diminishes in virulence after the larva has spun its cocoon, and is no longer active after the caterpillar is dead. 6. The poisonous spines cause localized necrosis of the human epidermis, followed by the formation of small vesicles. The cellular reaction to the poison is chiefly lymphocytic.

摘要

接触木蠹蛾幼虫的皮炎是由其表皮结节的中空、特化刚毛中导入的一种毒素引起的。它不是由装饰性毛发或动物的组织汁液引起的。
这种毒素似乎具有毒液的性质，与蛋白质载体结合，本身可能就是一种蛋白质。
它通过煮沸或加热至 55 摄氏度相当长的时间而失活。
它显然储存在刚毛基部的囊中，但它是在那里分泌的，还是由皮下腺分泌的，还有待确定。
幼虫结茧后，其毒性会减弱，毛毛虫死后，毒素不再活跃。
有毒的刺会导致人体表皮局部坏死，随后形成小水疱。对这种毒素的细胞反应主要是淋巴细胞。