Laboratories of The Rockefeller Institute for Medical Research.
J Exp Med. 1925 Jul 31;42(2):163-78. doi: 10.1084/jem.42.2.163.
A group of 350 normal rabbits was studied with reference to the occurrence of obscure lesions of various kinds and the probable or possible effect of such lesions or disease processes on organ weights. The results of the investigation are presented in the form of comparative tabulations. It was found that so long as the animals remained in apparently good health the values obtained for organ weights of animals with lesions did not differ materially from those for animals that were entirely free from lesions. There were, however, slight deviations from the normal which appeared to be significant in that they suggested a functional response similar in character to the more marked changes in mass and mass relationships that occur in rabbits presenting clinical symptoms of disease due to the same causes.
研究了一组 350 只正常兔子,观察各种隐匿性病变的发生情况,以及这些病变或疾病过程对器官重量的可能影响。调查结果以对比表格的形式呈现。结果发现,只要动物保持明显的健康状态,有病变的动物的器官重量值与完全没有病变的动物的器官重量值没有实质性差异。然而,有一些轻微的偏离正常,这些偏离似乎具有重要意义,因为它们表明存在一种功能反应,其性质与由于相同原因导致出现疾病临床症状的兔子中发生的更显著的质量和质量关系变化相似。