在一只野生鼠体内发现的螺旋体的实验研究，与引起鼠咬热的病原体相同：第二篇论文。
EXPERIMENTAL STUDIES WITH A SPIRAL ORGANISM FOUND IN A WILD RAT AND IDENTICAL WITH THE ORGANISM CAUSING RAT-BITE FEVER : SECOND PAPER.
机构信息
American Hospital, Mexico City, Mexico.
出版信息
J Exp Med. 1925 Sep 30;42(4):539-59. doi: 10.1084/jem.42.4.539.
Abstract
- The spiral organism isolated from a wild rat has proved identical with that from a human case of rat-bite fever in Mexico City. 2. Rabbits can easily be infected with these organisms. 3. The subcutaneous inoculation of them is followed after 3 to 5 days by a local edema, induration, and inflammation: primary lesion. 4. About 8 days after the appearance of the primary lesion, edematous swellings and inflammation appear on the head and genitals: secondary lesions. 5. The organism can be transmitted from rabbit to rabbit by coitus. 6. Protective antibodies are to be found in the blood of infected rabbits at a time when the local lesions are still active. The peculiar character of certain of the lesions is probably due to the escape of the antibodies from the blood stream. 7. The organism belongs to the genus Treponema.
摘要
- 从野生老鼠身上分离出的螺旋体与墨西哥城鼠咬热患者的病例中的螺旋体完全相同。2. 兔子很容易被这些生物体感染。3. 将它们皮下接种后，3 至 5 天后会出现局部水肿、硬结和炎症：原发性病变。4. 原发性病变出现后约 8 天，头部和生殖器会出现水肿性肿胀和炎症：继发性病变。5. 生物体可以通过交配从兔子传播到兔子。6. 感染兔子的血液中可以找到保护性抗体，此时局部病变仍处于活跃状态。某些病变的特殊性质可能是由于抗体从血流中逃逸所致。7. 该生物体属于密螺旋体属。
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